<p>Rounded tumor cells migrating in synthetic ECM (220 Pa, 1000 μM CRGDS): (<b>A</b>) Time-lapse images (15 min / frame; See also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0081689#pone.0081689.s022" target="_blank">Movie S11</a>) for a rounded HT-1080 after overnight swelling (day 1). (<b>B</b>) β1-integrin expression (immunofluorescence) for a rounded HT-1080. (<b>C</b>) Time-lapse images (10 min / frame; See also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0081689#pone.0081689.s023" target="_blank">Movie S12</a>) for a rounded HT-1080 shortly after encapsulation (Initial migration, Day 0). (<b>D</b>) Time-lapse images (30 min / frame) for a rounded WM239a melanoma cell after overnight swelling (day 1). Scale bars = 25 μm unless otherwise noted.</p
