β-catenin is important for maintenance of dorsoventral patterning of the retina.

Abstract

<p>(A–D) <i>In situ</i> hybridization analyses (A, C, D) and immunohistochemical analysis (B) on coronal sections of E9.5 (ss25–26) optic vesicles from control (left panels) and on <i>Lhx2-Cre:β-catenin^flox/flox</i> embryos (right panels). (E–H) In situ hybridization analyses (E, G, H) and immunohistochemical analysis (F) on coronal sections of E10.5 (ss32–34) optic cups from control (left panels) and <i>Lhx2-Cre:β-catenin^flox/flox</i> embryos (right panels). Black arrow heads in A and E, and white arrow heads in B and F, indicate the boundaries of the area where β-catenin has been inactivated. (I, J) <i>In situ</i> hybridization analyses on coronal sections of E10.5 (ss32–34) optic cups from control (left panel) and <i>Lhx2-Cre:β-catenin^flox/flox</i> embryos (right panels). (K, L) <i>In situ</i> hybridization analyses on coronal sections of an eye from E12.5 control (left panels) and <i>Lhx2-Cre:β-catenin^flox/flox</i> embryos. Dorsal-ventral (D–V) orientation of all panels is indicated in A. Scale bars: (A–E, G–J, F and K, L) 100 µm.</p