Selective Isomerization–Hydroformylation Sequence:
A Strategy to Valuable α‑Methyl-Branched Aldehydes from
Terminal Olefins
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Abstract
For
the first time, an original selective isomerization-hydroformylation
sequence to convert terminal olefins bearing an anionic moiety to
α-methyl-branched aldehydes with unprecedented selectivities
is reported. This opens up new synthetic avenues to these valuable
building blocks from inexpensive and bioavailable substrates. The
catalytic system involves a suitable selective monoisomerization catalyst
and a selective supramolecular catalyst that preorganizes a substrate
molecule prior to the hydroformylation reaction via hydrogen bonding.
In principle, the strategy can be extended to other classes of substrates,
providing suitable catalysts for the hydroformylation of internal
alkenes