A saturating period of MD reduces both excitatory and inhibitory responses to closed eye stimulation.

Abstract

<p><b>A</b>. Examples of excitatory (g<sub>E</sub>, red) and inhibitory (g<sub>I</sub>, green) responses of 4RSNs (left: normal; right: MD) upon stimulation with optimally oriented light bars. The total membrane conductance (G<sub>tot</sub>) is shown in blue and the V<sub>m</sub> response in absence of current injection is in black (top traces). Dotted lines: 0 nS. Gray shadow: 95% confidence intervals of the g<sub>E</sub> and g<sub>I</sub> estimates obtained by bootstrap analysis. <b>B</b>. Amplitudes of the visually-driven g<sub>E</sub> (green) and g<sub>I</sub> (red) responses in normal (open boxes) and MD (dashed boxes) rats. MD reduced both excitatory and inhibitory conductances upon contralateral eye (closed in MD rats) stimulation and increased both excitatory and inhibitory conductances upon ipsilateral eye (open in MD rats) stimulation (Mann-Whitney Rank Sum tests, p<0.05). <b>C</b>. The excitatory-inhibitory balance of visually-driven responses, expressed by the K<sub>EI</sub> index, was not affected by MD (dashed boxes vs open boxes) for both contralateral and ipsilateral responses (Mann-Whitney Rank Sum tests, p>0.7).</p

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