Asymmetric
Substitution at the Tetrasubstituted Chiral
Carbon: Catalytic Ring-Opening Alkylation of Racemic 2,2-Disubstituted
Aziridines with 3‑Substituted Oxindoles
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Abstract
A highly diastereo-
and enantioselective ring-opening alkylation
of racemic 2,2-disubstituted aziridines with 3-substituted oxindoles
is achieved under the catalysis of a chiral 1,2,3-triazolium salt.
This reaction represents a hitherto unknown, catalytic stereoselective
carbon–carbon bond formation through direct substitution at
the tetrasubstituted chiral carbon