Glucose
Sensor using Liquid-Crystal Droplets Made
by Microfluidics
- Publication date
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Abstract
Micrometer-sized,
4-cyno-4-pentylbiphenyl (5CB) droplets were developed
for glucose detection in an aqueous medium by coating with poly(acrylicacid-<i>b</i>-4-cynobiphenyl-4-oxyundecylacrylate) (PAA-<i>b</i>-LCP) at the 5CB/water interface and covalently immobilizing glucose
oxidase (GOx) to the PAA chains. This functionalized liquid-crystal
(LC) droplet detected glucose from a radial to bipolar configurational
change by polarized optical microscopy under crossed polarizers at
concentrations as low as 0.03 mM and response times of ∼3 min
and showed the selective detection of glucose against galactose. This
new and sensitive LC-droplet-based glucose biosensor has the merits
of low production cost and easy detection by the naked eye and might
be useful for prescreening the glucose level in the human body