Schematic representation of a PheWAS on a quantitative trait, analyzing ICD codes and biological test results.

Abstract

<p>PheWAS: Phenome-wide association study; ICD: International classification of diseases; TPMT: thiopurine <i>S</i>-methyltransferase. Patients are assigned to a group depending on the level of a quantitative trait (<i>e.g.</i> TPMT activity). ICD codes and biological test results are screened to find systematic differences between the groups.</p