Callyspongiolide, a Cytotoxic Macrolide from the Marine
Sponge <i>Callyspongia</i> sp.
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Abstract
A novel
macrolide, callyspongiolide, whose structure was determined
by comprehensive analysis of the NMR and HRMS spectra, was isolated
from the marine sponge <i>Callyspongia</i> sp. collected
in Indonesia. The compound features a carbamate-substituted 14-membered
macrocyclic lactone ring with a conjugated structurally unprecedented
diene-ynic side chain terminating at a brominated benzene ring. Callyspongiolide
showed strong cytotoxicity against human Jurkat J16 T and Ramos B
lymphocytes