An Enzyme-Responsive Controlled Release System of
Mesoporous Silica Coated with Konjac Oligosaccharide
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Abstract
A simple and green method to fabricate
an ingenious enzyme-responsive
drug controlled release system was presented. Mesoporous silica material
(mSiO<sub>2</sub>) 100 nm in size was used as the host, and Konjac
oligosaccharide (KOGC) was employed to seal the nanopores of mSiO<sub>2</sub> to inhibit the drug release. Rhodamine B was used as the
model cargo to reveal the release behavior of the system. The KOGC-modified
mSiO<sub>2</sub> (mSiO<sub>2</sub>@KOGC) retains the drug until it
reaches the colonic environment where bacteria secrete enzymes (β-mannanase)
can degrade KOGC and make drug release. The amount of KOGC and enzyme
can be used to adjust the release performance. And all the release
behaviors fit the two-step Higuchi model, which predominate by KOGC
degradation and mesoporous structure, respectively. With well bioactivity
and selectivity, the system has potential application as an oral medicine
carrier for treating intestinal disease