<p><i>A–B</i>. qPCR of NLRP2 (<i>A</i>) and <i>ASB9</i> (<i>B</i>) from mRNA from Brodmann's area (BA38) from control and AD brains. Black bars (1–5) are controls and red bars represent AD patients (6–16), which are described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0084547#pone.0084547.s005" target="_blank">Fig S5</a>. qPCR data was normalized internally to <i>GAPDH</i> expression and also to the average of 5 control lines. Statistical significance was determined by Student's t-Test and error bars reflect SEM. For control vs. AD, n = 5 for control, n = 11 for AD, p = 0.005. <i>C</i>. List of <i>PSEN1</i> NPC target genes (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0084547#pone.0084547.s008" target="_blank">Table S2</a>) that have differential expression in independent microarray data of laser captured microdissected (LCM) cortical neurons from one of three brain areas (details in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0084547#pone.0084547.s005" target="_blank">Fig S5</a>). All comparisons are either non-demented AD pathology (NDAD) or AD versus control samples. HIP refers to hippocampus, EC for entorhinal cortex, and MTG for middle temporal gyrus. Fold change and significance (FDR: false discover rate) reflect values for LCM neuron arrays. See also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0084547#pone.0084547.s004" target="_blank">Figure S4</a>.</p
