Combinatorial Synthesis of Oxazol-Thiazole Bis-Heterocyclic
Compounds
- Publication date
- Publisher
Abstract
A combinatorial library of novel
oxazol-thiazole bis-heterocycles
was synthesized in good to excellent overall yields with high purity
using a solution and solid-phase parallel synthesis approach. Oxazole
amino acids, prepared from serine methyl ester and amino acids via
coupling and cyclodehydration, were treated with Fmoc-NCS and α-haloketones
for the parallel synthesis of diverse bis-heterocycles. Fmoc-isothiocyanate
is used as a traceless reagent for thiazole formation. Oxazole diversity
can be achieved by using variety of amino acids, whereas thiazole
diversity is produced with various haloketones