Aminolysis of Aryl Ester Using
Tertiary Amine as Amino
Donor via C–O and C–N
Bond Activations
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Abstract
An aminolysis reaction between various
aryl esters and inert tertiary
amines by C–O and C–N bond activations has been developed
for the selective synthesis of a broad scope of tertiary amides under
neutral and mild conditions. The mechanism may undergo the two key
steps of oxidative addition of acyl C–O bond in parent ester
and C–N bond cleavage of tertiary amine via an iminium-type
intermediate