A Direct Approach to a 6‑Hetarylamino[1,2,4]triazolo[4,3‑<i>b</i>][1,2,4,5]tetrazine Library
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Abstract
The
synthesis of 6-hetarylamino[1,2,4]triazolo[4,3-<i>b</i>][1,2,4,5]tetrazines
is reported. The functionalized secondary amines
were constructed via a K<sub>2</sub>CO<sub>3</sub>-mediated S<sub>N</sub>Ar reaction of weakly basic hetarylamines with 3-(3,5-dimethylpyrazol-1-yl)[1,2,4]triazolo[4,3-<i>b</i>][1,2,4,5]tetrazines, which allowed displacement 3,5-dimethylpyrazolyl
leaving group. Significantly, the reaction exhibited a broad substrate
scope and proceeded in good yields