DNA-damage–induced mutagenesis is abolished in <i>def1</i> deletion mutants.

Abstract

<p>Forward mutation rates at the <i>CAN1</i> locus were determined after UV treatment. Where indicated, <i>def1</i> deletion was complemented by wild-type <i>DEF1</i> expressed under the control of the ADH1 promoter on a centromeric plasmid. The standard deviation is indicated above each bar. Experiments were repeated three times.</p