<p>Effect of increasing concentrations of GYY4137 on mesenteric artery segments with intact or removed endothelium was examined in the absence or in the presence of K<sup>+</sup> channel inhibitors and R<sub>max</sub> and EC<sub>50</sub> values were calculated for each preparation (n = 6/group).</p>***<p>p<0.001 vs. preparation without K<sup>+</sup> channel inhibitors (Student t-test for related variables),</p>†††<p>p<0.001 vs. segments with intact endothelium (Student t-test for unrelated variables). Because glibenclamide almost completely abolished the effect of GYY4137 in endothelium-denuded segments, R<sub>max</sub> and EC<sub>50</sub> could not be calculated.</p
