HIV-RNA and CD4 values and estimated CD4 slope during elite control (EC), and throughout ART-naïve follow-up using the CASCADE dataset applied to 10 definitions of EC found in the literature.

Abstract

<p>Note- all values unless otherwise stated are median (IQR).</p>†<p>CD4 slope modelled on the square root scale with linear mixed models, specific p-values for CD4 slope and median number of CD4 measurements are presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086719#pone.0086719.s001" target="_blank">Table S1</a>.</p>‡<p>CD4 slope highly significant p<0.001.</p><p>Ŧ Number of total CD4 and HIV-RNA measurements <b><sup>ŧ</sup> A</b>: HIV-positive ≥6 months, with ≥2 consecutive HIV-RNA <75 copies/ml; <b>B</b>: HIV- positive ≥1 year, with ≥1 HIV-RNA <50 copies/ml, <b>C</b>: HIV- positive ≥1 year, with ≥1 HIV-RNA <75 copies/ml, <b>D</b>: HIV- positive ≥1 year, with ≥3 HIV-RNA <2000 copies/ml, <b>E</b>: HIV- positive ≥1 year, with ≥3 consecutive HIV-RNA <75 copies/ml spanning ≥12 months <b>F</b>: HIV- positive ≥1 year, with ≥3 consecutive HIV-RNA <75 copies/ml spanning ≥12 months with no previous blips ≥1000 copies/ml, <b>G</b>:HIV- positive ≥2 years, with ≥2 HIV-RNA <75 copies/ml, <b>H</b>: HIV- positive ≥5 years, with ≥5 consecutive HIV-RNA <500 copies/ml, <b>I</b>: HIV- positive ≥10 years, with all measured HIV-RNA <50 copies/ml, <b>J</b>: HIV-positive ≥10 years, with ≥90% of HIV-RNA (≥2 HIV-RNA ever) <400 copies/ml.</p

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