Efficient
Phosphodiester Cleaving Nanozymes Resulting
from Multivalency and Local Medium Polarity Control
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Abstract
The
self-organization of Zn(II) complexes on the surface of 1.6-nm
diameter gold nanoparticles (nanozymes) allows the spontaneous formation
of multiple bimetallic catalytic sites capable to promote the cleavage
of a RNA model substrate. We show that by tuning the structure of
the nanoparticle-coating monolayer, it is possible to decrease the
polarity of the reaction site, and this in turn generates remarkable
increments of the cleavage efficiency
