A New Strategy To Construct Acyclic Nucleosides via Ag(I)-Catalyzed Addition of Pronucleophiles to 9‑Allenyl‑9<i>H</i>‑purines

Abstract

A new strategy to construct acyclic nucleosides with diverse side chains was developed. With Ag­(I) salts as catalysts, the hydrocarboxylation, hydroamination, and hydrocarbonation reactions proceeded well, affording acyclic nucleosides in good yields (41 examples, 60–98% yields). Meanwhile, these reactions exhibited high chemoselectivities and <i>E</i>-selectivities