Chemical
Composition, Antioxidant and Anti-AGEs Activities
of a French Poplar Type Propolis
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Abstract
Accumulation in tissues and serum
of advanced glycation end-products
(AGEs) plays an important role in pathologies such as Alzheimer’s
disease or, in the event of complications of diabetes, atherosclerosis
or renal failure. Therefore, there is a potential therapeutic interest
in compounds able to lower intra and extracellular levels of AGEs.
Among them, natural antioxidants (AO) with true anti-AGEs capabilities
would represent good candidates for development. The purpose of this
study was to evaluate the AO and anti-AGEs potential of a propolis
batch and then to identify the main compounds responsible for these
effects. In vivo, protein glycation and oxidative stress are closely
related. Thus, AO and antiglycation activities were evaluated using
both DPPH and ORAC assays, respectively, as well as a newly developed
automated anti-AGEs test. Several propolis extracts exhibited very
good AO and anti-AGEs activities, and a bioguided fractionation allowed
us to identify pinobanksin-3-acetate as the most active component