Synthesis, Cytostatic, Antimicrobial,
and Anti-HCV
Activity of 6‑Substituted 7‑(Het)aryl-7-deazapurine
Ribonucleosides
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Abstract
A series of 80 7-(het)aryl-
and 7-ethynyl-7-deazapurine ribonucleosides
bearing a methoxy, methylsulfanyl, methylamino, dimethylamino, methyl,
or oxo group at position 6, or 2,6-disubstituted derivatives bearing
a methyl or amino group at position 2, were prepared, and the biological
activity of the compounds was studied and compared with that of the
parent 7-(het)aryl-7-deazaadenosine series. Several of the compounds,
in particular 6-substituted 7-deazapurine derivatives bearing a furyl
or ethynyl group at position 7, were significantly cytotoxic at low
nanomolar concentrations whereas most were much less potent or inactive.
Promising activity was observed with some compounds against <i>Mycobacterium bovi</i>s and also against hepatitis C virus in
a replicon assay