Mild and Selective Heterogeneous Catalytic Hydration
of Nitriles to Amides by Flowing through Manganese Dioxide
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Abstract
A sustainable flow
chemistry process for the hydration of nitriles,
whereby an aqueous solution of the nitrile is passed through a column
containing commercially available amorphous manganese dioxide, has
been developed. The product is obtained simply by concentration of
the output stream without any other workup steps. The protocol described
is rapid, robust, reliable, and scalable, and it has been applied
to a broad range of substrates, showing a high level of chemical tolerance