Aldehydes and Ketones Formation:
Copper-Catalyzed
Aerobic Oxidative Decarboxylation of Phenylacetic Acids and α‑Hydroxyphenylacetic
Acids
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Abstract
Aromatic aldehydes or ketones from
copper catalyzed aerobic oxidative
decarboxylation of phenylacetic acids and α-hydroxyphenylacetic
acids have been synthesized. This reaction combined decarboxylation,
dioxygen activation, and C–H bond oxidation steps in a one-pot
protocol with molecular oxygen as the sole terminal oxidant. This
reaction represents a novel decarboxylation of an <i>sp</i><sup>3</sup>-hybridized carbon and the use of a benzylic carboxylic
acid as a source of carbonyl compounds