<p>(a) Example Venn diagrams showing the overlap of binding and differential expression for the knockdowns of <i>HCST</i> and <i>IRF4</i> (the same genes as in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004226#pgen-1004226-g001" target="_blank">Figure 1</a>). (b) Boxplot summarizing the distribution of the fraction of all expressed genes that are bound by the targeted gene or downstream factors. (c) Boxplot summarizing the distribution of the fraction of bound genes that are classified as differentially expressed, using an FDR of either 5% or 20%.</p