Abstract

<p>(A) Graphic illustration of FLT3 mutants with respect to biological characteristics according to performed experiments. FLT3 mutants were clustered hierarchically based on similarity and displayed in columns. Experiments were ordered in rows as indicated. (B) Heatmap of probe sets differentially expressed in <i>FLT3</i>-ITD, -TKD and -WT CN-AML. The 27 probe sets were selected according to FLT3 and NPM1 mutation status (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0089560#pone.0089560.s005" target="_blank">Table S3</a>) with following characteristics: Log fold change &gt; or &lt;1.5. If no probe set met this criterion, the ten most significant probe sets were selected. Rows: probe sets (n = 27); Columns: patients (n = 213).</p

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