Abstract

<p>CD34+ cells were cultured in the presence of G-CSF to induce neutrophil differentiation in the absence or presence of 0.5 µM (patient 1) or 1.0 µM (patient 2–3) NTS1 and NTS2. Cells were isolated after 3 days for CFU assays in the presence of G-CSF during 11 days. Data were expressed as the number of CFU-GM (A, upper panel), CFU-G (<b>A, middle panel</b>) and CFU-M (<b>A, lower panel</b>) for each patient and for all patients together (<b>B</b>). Progenitor expansion and terminal differentiation was evaluated after 14 days, Data were expressed as fold induction (<b>C</b>) and the percentage of mature neutrophils and monocytes (<b>D</b>). Error bars represent SEM (between patients). *p = <0.05.</p

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