Voltage-Dependent Properties of DNA Origami Nanopores
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Abstract
We show DNA origami nanopores that
respond to high voltages by
a change in conformation on glass nanocapillaries. Our DNA origami
nanopores are voltage sensitive as two distinct states are found as
a function of the applied voltage. We suggest that the origin of these
states is a mechanical distortion of the DNA origami. A simple model
predicts the voltage dependence of the structural change. We show
that our responsive DNA origami nanopores can be used to lower the
frequency of DNA translocation by 1 order of magnitude