CD103⁺ DCs and CD8⁺ DCs have differential capacity to induce Th17 upon viral infection.

Abstract

<p>(A) Proliferation of 5×10⁴ CFSE-labeled HSV-specific CD4⁺ T cells (gDT-II) after 60 h of culture together with serial dilutions of DC subsets isolated from brachial lymph nodes of mice infected withn HSV 5 d earlier. (B) Culture supernatants from (A) were measured for the indicated cytokines. (C) Proliferation and cytokine production with isolated DCs and exogenous source of antigenic peptide. Data (mean ± SEM) are one of two individual experiments. (**P<0.01; Two tailed Student's T test).</p