Palladium-Catalyzed Alkenylation
via sp<sup>2</sup> C–H Bond Activation Using Phenolic Hydroxyl
as the Directing
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Abstract
This note describes
the efficient and highly regioselective synthesis
of 2-(2′-alkenylphenyl)phenol derivatives via palladium-catalyzed
2′-alkenylation of 2-arylphenols directed by the phenolic hydroxyl
group using benzoquinone as the oxidant in an atmosphere of air. This
reaction can tolerate a series of functional groups and provides the
alkenylation products regio- and stereoselectively in moderate to
good yields