<p>(<b>A</b>) Protein dynamics studies of XPC in the nuclei of human fibroblasts. Cells were transfected with the XPC-EGFP construct, incubated with 5 μM cisplatin and subjected to FRAP analysis (N = 30; error bars, S.E.M.). The resulting fluorescence recovery curves were compared to those of untreated controls (*p<0.05). (<b>B</b>) FRAP studies (N = 50) demonstrating that the fluorescence recovery curves of XPC-EGFP are not affected by an 18-h formaldehyde treatment (75 μM). (<b>C</b>) FRAP analysis of transfected fibroblasts demonstrating that the 18-h formaldehyde treatment (75 μM) does not further reduce the delayed XPC-EGFP trafficking in UV-irradiated cells (30 J/m<sup>2</sup>; N = 50). (<b>D</b>) Combined formaldehyde treatment and DDB2 overexpression. The transfected fibroblasts were exposed to 75 μM formaldehyde for 18 h and subjected to FRAP analysis. The presence of DDB2-RFP resulted in a slightly delayed fluorescence recovery curve of XPC-EGFP upon formaldehyde exposure (N = 30). Asterisks, significant differences between formaldehyde-treated and untreated fibroblasts (*p<0.05).</p
