<p>(<b>A</b>) Representative image illustrating the redistribution of DDB2 to UV lesion sites visualized with antibodies against (6-4) photoproducts. Human fibroblasts transfected with DDB2-EGFP were UV-irradiated through the pores of polycarbonate filters and fixed 15 min after treatment. DNA is evidenced by the Hoechst reagent and the nuclei are shown with contrast images. (<b>B</b>) Representative cells demonstrating the defective translocation of DDB2-EGFP from undamaged nuclear areas to UV lesions after 18-h incubations with 75 μM formaldehyde. (<b>C</b>) Representative images illustrating that the 75-μM formaldehyde treatment impedes the redistribution of XPC-EGFP to UV lesions. (<b>D</b>) Reduced fluorescence intensity at UV lesion spots over the surrounding background in cells exposed for 18 h to 75 μM formaldehyde (N = 54; error bars, S.D.; *p<0.05, **p<0.01).</p
