<p>Prevalence of TDRM is shown for any of the drug classes (any class), nucleoside reverse transcriptase inhibitor (NRTI), non-nucleoside reverse transcriptase inhibitor (NNRTI) and protease inhibitor (PI) in <b>(A)</b> Men having sex with men (MSM), and in <b>(B)</b> heterosexuals (HSX). The p-values of the time trends are shown on the right side of the graph.</p