Temperature-Driven Switching of the Catalytic Activity
of Artificial Glutathione Peroxidase by the Shape Transition between
the Nanotubes and Vesicle-like Structures
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Abstract
Smart
supramolecular nanoenzymes with temperature-driven switching
property have been successfully constructed by the self-assembly of
supra-amphiphiles formed by the cyclodextrin-based host–guest
chemistry. The self-assembled nanostructures were catalyst-functionalized
and thermosensitively-functionalized through conveniently linking
the catalytic center of glutathione peroxidase and thermosensitive
polymer to the host cyclodextrin molecules.The ON–OFF switches
for the peroxidase activity by reversible transformation of nanostructures
from tube to sphere have been achieved through changing the temperature.
We anticipate that such intelligent enzyme mimics could be developed
to use in an antioxidant medicine with controlled catalytic efficiency
according to the needs of the human body in the future