Structural location of selected EGFR mutation sites.

Abstract

<p>Protein crystal structure [PDB∶2JIU] shown as cartoon, with sites G724, T725, L858 and L861 shown as spheres. Structural regions highlighted in yellow are kinase subdomain I and the activation loop. The structure image was generated using PyMOL <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003545#pcbi.1003545-Delano1" target="_blank">[75]</a>.</p