Precise Tuning of Cationic Cyclophanes toward Highly
Selective Fluorogenic Recognition of Specific Biophosphate Anions
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Abstract
Cationic cyclophanes
with bridging and spacer groups possess well-organized
semirigid cavities and are able to encapsulate and stabilize anionic
species through diverse molecular interactions. We highlight the precise
tuning of functionalized cyclophanes toward selective recognition
of AMP, GTP, and pyrophosphate (PPi) using fluorescence, NMR spectroscopy,
and density functional theory (DFT)