Marsupellins A–F, <i>ent</i>-Longipinane-Type Sesquiterpenoids from the Chinese Liverwort <i>Marsupella alpine</i> with Acetylcholinesterase Inhibitory Activity

Abstract

Acetylcholinesterase (AChE) inhibitory activity-guided fractionation of the Chinese liverwort <i>Marsupella alpine</i> afforded six new [marsupellins A–F (<b>1</b>–<b>6</b>)] and three known (<b>7</b>–<b>9</b>) <i>ent</i>-longipinane-type sesquiterpenoids. The structures were determined from MS and NMR spectroscopic data, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Compounds <b>1</b>–<b>9</b> exhibited moderate to weak AChE inhibitory activity