A,D-<i>seco</i>-Limonoids from the Stems
of <i>Clausena emarginata</i>
- Publication date
- Publisher
Abstract
Twelve new A,D-<i>seco</i>-limonoids, clauemargines A–L
(<b>1</b>–<b>12</b>), and three known analogues
were isolated from the stems of <i>Clausena emarginata</i>. The absolute configurations of <b>1</b> and <b>5</b> were confirmed by X-ray crystallography and ECD spectroscopy, respectively.
Compounds <b>1</b>, <b>2</b>, <b>8</b>–<b>10</b>, and <b>13</b> showed moderate inhibitory effects
on LPS-induced NO production (IC<sub>50</sub> values < 10 μM)
