Potential Anti-angiogenesis Effects of <i>p</i>‑Terphenyl Compounds from <i>Polyozellus multiplex</i>

Abstract

One novel <i>p</i>-terphenyl compound, polyozellic acid (<b>1</b>), and its acetone adduct (<b>3</b>), along with a known <i>p</i>-terphenyl compound, thelephoric acid (<b>2</b>), were isolated from the mushroom <i>Polyozellus multiplex</i>. Their molecular structures were determined by spectroscopic analysis, X-ray crystallographic analysis, and chemical modification. In some assays related to angiogenesis, compounds <b>1</b> and <b>2</b> in particular showed inhibitory effects on proliferation, tubule formation, and invasion of human umbilical vein endothelial cells. The quinone moiety within these molecules possibly contributes to their antiangiogenesis activity