'Royal College of Obstetricians & Gynaecologists (RCOG)'
Abstract
In vivo, cis-dichlorodiammineplatinum(II) (I) [15663-27-1] and cis-dichlorobis(glycylglycine Et ester)platinum(II) (II) [60426-60-0] inhibited the DMBA-induced hormone-dependent mammary carcinoma of the SD rat. In vitro, a marked effect on DNA synthesis by mammary tumor cells and an inhibition of estradiol-receptor interaction by I and II were demonstrated. Binding to DNA and inhibition of the proliferation-stimulating effect of endogenous estrogens by blocking the hormone receptors are discussed as modes of action of I and II
