Irregular lesions in ColI(2.3)⁺/Rs1⁺ cochlea involve the apex and the labyrinth causing thickening of the otic capsule.

Abstract

<p>(<b>A–C</b>) Cochlea from 12-week-old WT and ColI(2.3)⁺/Rs1⁺ mice were stained for toluidine blue and examined histologically. Mixed boney fibrous lesions were often observed surrounding ColI(2.3)⁺/Rs1⁺ cochlea compared to WT controls. ColI(2.3)⁺/Rs1⁺ cochlea had multiple fibrous boney overgrowths of the vestibular bone compared to normal WT morphology. Scale bar, 150 µm. (<b>D–F</b>) The walls of ColI(2.3)⁺/Rs1⁺ cochleae showed significant thickening in comparison to WT cochleae, possibly due to the overall thickening of the surrounding otic capsule. The stria vascularis (SV) in the ColI(2.3)⁺/Rs1⁺ mice appear normal. Scale bar, 100 µm.</p