Pentafluorosulfanyl­di­fluoroacetic Acid: Rebirth of a Promising Building Block

Abstract

Three novel, easily scalable routes for the synthesis of penta­fluoro­sulfanyl­di­fluoro­acetic acid, SF₅CF₂C­(O)­OH, are described. Reactions of its acid chloride with amines and alcohols led to a small library of 15 amides and five esters, respectively. The reaction of the acid chloride with phenyl­magnesium bromide gave the corresponding aceto­phenone. Penta­fluoro­sulfanyl­difluoro­aceto­nitrile was obtained from penta­fluoro­sulfanyl­di­fluoro­acetamide by dehydration with diphosphorus pentoxide