Pentafluorosulfanyldifluoroacetic Acid:
Rebirth of a Promising Building Block
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Abstract
Three novel, easily scalable routes
for the synthesis of pentafluorosulfanyldifluoroacetic
acid, SF<sub>5</sub>CF<sub>2</sub>C(O)OH, are described. Reactions
of its acid chloride with amines and alcohols led to a small library
of 15 amides and five esters, respectively. The reaction of the acid
chloride with phenylmagnesium bromide gave the corresponding
acetophenone. Pentafluorosulfanyldifluoroacetonitrile
was obtained from pentafluorosulfanyldifluoroacetamide
by dehydration with diphosphorus pentoxide