Rhodium-Catalyzed Asymmetric Hydrogenation of β‑Acetylamino Acrylosulfones: A Practical Approach to Chiral β‑Amido Sulfones

Abstract

The efficient and highly enantioselective catalytic asymmetric hydrogenation of β-acetylamino acrylosulfone has been achieved by employing Rhodium-TangPhos as catalyst. A series of β-amido sulfone products are obtained with excellent yields and good enantioselectivities