Charged
Polymer Brushes-Grafted Hollow Silica Nanoparticles
as a Novel Promising Material for Simultaneous Joint Lubrication and
Treatment
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Abstract
The
fabrication of core/shell charged polymer brushes-grafted hollow
silica nanoparticles (PSPMA-<i>g</i>-HSNPs) is reported.
Because of the excellent hydration capability of the shells consisting
of charged polymer brushes, the functional nanoparticles can achieve
a good lubricating effect in aqueous media via hydration lubrication
mechanism. The mesoporous hollow silica cores endow the nanoparticles
with drug loading–release capability. Aspirin, as a useful
drug for treating arthritis, was employed to carry out in vitro drug
loading and release studies. It is clear that brushes-modified hollow
silica exhibited long-term drug release performance. The combination
of lubrication and drug loading capabilities results in the great
clinical potential of new multifunctional nanoparticles as injectable
joint lubricant fluid in arthritis treatment