<p>(A) The mRNA level of <i>AR</i> was not affected at PD21.5. The <i>ERα</i> level was upregulated significantly in the 12 mg/kg/day-exposure group, and there was an increasing trend in the other exposure group. <i>Pcna</i> expression was not altered. (B) <i>AR</i> expression was downregulated significantly in the exposure groups, and <i>ERα</i> and <i>Pcna</i> were upregulated, which may explain the hyperplasia of interstitial cells. (C) <i>AR</i> and <i>Pcna</i> were downregulated significantly, and <i>ERα</i> was upregulated, as observed at PD21.5 and PD45.5. (D) Serum T and E<sub>2</sub> levels and the E<sub>2</sub>/T ratio at the three time points. The T level was lower, and the E<sub>2</sub> level was higher in the CYP exposure groups at PD45.5 and PD90.5. The data represent the mean ± SEM. *<i>P</i><0.05.</p
