Radical <i>ipso</i>-Substitution of a Carbon–Fluorine Bond Leading to Fluoro-7-azaindolines and Fluoro-7-azaindoles

Abstract

Rare examples of a synthetically useful radical <i>ipso</i>-substitution of a carbon–fluorine bond are reported, leading to highly functionalized 5,6-difluoro-7-azaindolines. An unexpected hydrogen atom translocation and fragmentation with loss of molecular nitrogen and formation of a nitrile were observed in the case of an <i>N</i>-benzyl-tetrazole derivative