Nickel-Catalyzed Cross-Coupling
of Aryl Fluorides
and Organozinc Reagents
- Publication date
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Abstract
Ni(PCy<sub>3</sub>)<sub>2</sub>Cl<sub>2</sub> was demonstrated
to effectively catalyze cross-coupling of aryl fluorides and organozinc
reagents. Both electron-poor and -rich aryl fluorides can react effectively
with nucleophiles including aryl-, methyl-, and benzylzinc chlorides.
A wide range of substituents and functional groups are tolerated.
In the presence of a directing group, PhC(O), the reaction is selective
for cleavage of the C–F bond <i>ortho</i> to the
carbonyl substituent in a difluoroarene
