A Facile
Bifunctional Strategy for Fabrication of
Bioactive or Bioinert Functionalized Organic Surfaces via Amides-Initiated
Photochemical Reactions
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Abstract
The excellent potential of organic
polymeric materials in the biomedical
field could be exploited if their interfacial problem could be fully
resolved. A necessary prerequisite to this purpose often involves
the simple but effective synthesis of a bioactive surface to endow
polymer surfaces with high reactivity toward efficient biomolecules
conjugation and a bioinert surface to prevent nonspecific adsorption
of nontarget biomolecules. Although the corresponding research has
been an important topic, actually few strategies could pave the way
to comprehensively and simply tackle both of the bioactive and bioinert
surfaces preparation issues. Herein we report an extremely simple
and integrative bifunctional method that could efficiently tailor
an organic material surface toward both bioactive and bioinert functions.
This method is based on the use of an amides-initiated photochemical
reaction in a confined space, which depending on the type of solutes
used, results in the incorporation of primary amine groups or surface
carbon radicals on an inert polymer surface. The grafted amine group
could be used as a highly reactive site for biomolecule conjugation,
and the surface carbon radical could be used to initiate radical graft
polymerization of antifouling polymer brushes. We expect this simple
but powerful method could provide a general resolution to solve the
interfacial problem of organic substrate, offering a low-cost practical
approach for real biomedical applications