Strong tumour cytidine deaminase (CDA) staining predicts for improved survival associated with sequential nab-Paclitaxel (nabP) and gemcitabine (GEM) chemotherapy as first line treatment of patients (pts) with metastatic pancreatic adenocarcinoma (mPDAC)

Abstract

Two analogous metal–organic frameworks (MOFs) with the perovskite architecture, [C­(NH₂)₃]­[Mn­(HCOO)₃] (<b>1</b>) and [(CH₂)₃NH₂]­[Mn­(HCOO)₃] (<b>2</b>), exhibit significantly different mechanical properties. The marked difference is attributed to their distinct modes of hydrogen bonding between the A-site amine cation and the anionic framework. The stronger cross-linking hydrogen bonding in <b>1</b> gives rise to Young’s moduli and hardnesses that are up to twice those in <b>2</b>, while the thermal expansion is substantially smaller. This study presents clear evidence that the mechanical properties of MOF materials can be substantially tuned via hydrogen-bonding interactions