CuI-Catalyzed C–N Bond Formation and Cleavage for the Synthesis of Benzimidazo[1,2‑<i>a</i>]quinazoline Derivatives

Abstract

A copper­(I)-catalyzed domino reaction of <i>N</i>-(2-benzimidazolyl)-2-aminobenzamide and 2-halogenated benzaldehyde has been studied. The procedure is based on a sequential CuI-catalyzed Ullmann reaction (C–N bond formation) and two bond cleavage reactions and provides an efficient strategy for the synthesis of benzimidazo­[1,2-<i>a</i>]­quinazolines catalyzed by CuI/l-proline