Meroterpenoids
from the Alga-Derived Fungi <i>Penicillium thomii</i> Maire
and <i>Penicillium lividum</i> Westling
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Abstract
Ten new austalide meroterpenoids
(<b>1</b>–<b>10</b>) were isolated from the alga-derived
fungi <i>Penicillium thomii</i> KMM 4645 and <i>Penicillium
lividum</i> KMM 4663. Their
structures were elucidated by extensive spectroscopic analysis and
by comparison with related known compounds. The absolute configurations
of some of the metabolites were assigned by the modified Mosher’s
method and CD data. Compounds <b>1</b>, <b>2</b>, <b>8</b>, and <b>9</b> were able to inhibit AP-1-dependent
transcriptional activity in JB6 Cl41 cell lines at noncytotoxic concentrations.
Austalides <b>1</b>–<b>5</b>, <b>8</b>, and <b>9</b> exhibited significant inhibitory activity against <i>endo</i>-1,3-β-d-glucanase from a crystalline
stalk of the marine mollusk <i>Pseudocardium sachalinensis</i>