<p>The arrows and T-shaped lines signify positive and negative actions, respectively. The thickness of each line is proportional to the strength of the denoted action. The dashed green line and arrow indicate that these actions were verified by another group <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0100124#pone.0100124-Lee1" target="_blank">[10]</a>. The red and blue arrows indicate up-regulation and down-regulation, respectively. Down-regulation of GAK leads to hyper-phosphorylation of tyrosine residues (pY) in EGFR.</p
